Joseph Yousefian, DMD, MS, MA; Kate Weaver, DDS; Douglas Trimble, DMD, MD; Robert William DePaso, MD; and Robert Gottlieb, DDS; discuss obstructive sleep apnea syndrome and describe a comprehensive and interdisciplinary treatment that successfully addressed the patient?s dentofacial aesthetic concerns and other health issues. This article is peer-reviewed and available for 2 hours of CE credit. Learning Objectives: After participating in this CE activity, the individual will learn: Definition and complications of obstructive sleep apnea syndrome (OSAS). Interdisciplinary treatment, dentofacial aesthetic concerns, and other health issues involving OSAS.