Herbert Bader, DDS, discusses the clinical presentations of various human papillomavirus (HPV)-related oral lesions and their associated HPV genotypes as well as contemporary adjunctive technologies for oral cancer screening. This article is peer-reviewed and available for 2 hours of CE credit. Learning Objectives: After participating in this CE activity, the individual will learn: The clinical presentations of various human papillomavirus (HPV)-related oral lesions and their associated HPV genotypes. Contemporary adjunctive technologies for oral cancer screening