Alison Glascoe, DDS, MS; Ronald Brown, DDS, MS; and Motshabi Makhene, DDS; discuss the relationship between oral health and systemic health, specifically the relationship between periodontal disease and cardiovascular disease. This article is peer-reviewed and available for 2 hours of CE credit. Learning Objectives: After reading this article, the individual will learn: (1) what periodontal medicine is and (2) current state of the medical and dental literature regarding the association between periodontal disease and hypertension, atherosclerotic diseases, metabolic syndrome, and obesity.